- Johnson, A.B., et al. (2023). “Nutrient synergies and interactions: Implications for supplement formulation and ef[1] Lugo JP, Saiyed ZM, Lau FC, et al. Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. J Int Soc Sports Nutr. 2013
- Bagchi D, Misner B, Bagchi M, et al. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 2002
- Tong T, Zhao W, Wu YQ, et al. Chicken type II collagen induced immune balance of main subtype of helper T cells in mesenteric lymph node lymphocytes in rats with collagen-induced arthritis. Inflamm Res. 2010
- Zhu P, Li XY, Wang HK, et al. Oral administration of type-II collagen peptide 250-270 suppresses specific cellular and humoral immune response in collagen-induced arthritis. Clin Immunol. 2007
- Crowley DC, Lau FC, Sharma P, et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009
- Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J. 2016
- Lugo JP, Saiyed ZM, Lau FC, et al. Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. J Int Soc Sports Nutr. 2013
- Benson KF, Ruff KJ, Jensen GS. Effects of natural eggshell membrane (NEM) on cytokine production in cultures of peripheral blood mononuclear cells: increased suppression of tumor necrosis factor-α levels after in vitro digestion. J Med Food. 2012
- Park KS, Park MJ, Cho ML, et al. Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis. Mod Rheumatol. 2009
- Weiner HL, da Cunha AP, Quintana F, Wu H. Oral tolerance. Immunol Rev. 2011
- Bagchi D, Misner B, Bagchi M, et al. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 2002
- Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial. Eurasian J Med. 2016
- Mehra A, Anand P, Bhatia CS, et al. A randomized, controlled study to evaluate the efficacy and safety of UC-II in subjects with exercise-induced joint discomfort. Appl Physiol Nutr Metab. 2019
- Murad S, Grove D, Lindberg KA, Reynolds G, Sivarajah A, Pinnell SR. Regulation of collagen synthesis by ascorbic acid. Proc Natl Acad Sci USA. 1981
- DePhillipo NN, Aman ZS, Kennedy MI, Begley JP, Moatshe G, LaPrade RF. Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthop J Sports Med. 2018
- Agarwal P, Schulz JN, Blumbach K, et al. Enhanced denaturation of the alpha 2(I) chain of type I collagen in Wistar rats by the aminoterminal propeptide. J Biol Chem. 2013
- Di Cesare Mannelli L, Micheli L, Zanardelli M, Ghelardini C. Low dose native type II collagen prevents pain in a rat osteoarthritis model. BMC Musculoskelet Disord. 2013
- DeGroot J, Verzijl N, Wenting-van Wijk MJ, et al. Age-related decrease in susceptibility of human articular cartilage to matrix metalloproteinase-mediated degradation: the role of advanced glycation end products. Arthritis Rheum. 2001
- Verzijl N, DeGroot J, Thorpe SR, et al. Effect of collagen turnover on the accumulation of advanced glycation end products. J Biol Chem. 2000
- Roman-Blas JA, Castañeda S, Largo R, Herrero-Beaumont G. Osteoarthritis associated with estrogen deficiency. Arthritis Res Ther. 2009
Nourish® Awards 2024
3 Star-Finalist Beauty & Collagen Category
Your body’s joint health naturally declines with age, stress, and physical activity—and standard collagen supplements are poorly absorbed, leaving you with minimal benefits despite your investment.
Optimcell® Liposomal Collagen II solves this with precision-engineered liposomal encapsulation that protects each dose through your digestive system. Our advanced delivery system ensures UC-II® undenatured collagen and Vitamin C reach your system intact, providing powerful joint support, enhanced mobility, and essential protection for your connective tissues against daily wear and tear.
This isn’t just another collagen supplement—it’s collagen type II finally delivered the way your body can actually use it. Feel the difference that true absorption makes.

Collagen Type II: Superior Joint Support, Enhanced Mobility & Stronger Connective Tissues
Understanding Collagen Types: Why Type II Matters for Joint Health
Collagen is the most abundant protein in your body, but not all collagen is the same. There are at least 28 different types, each serving specific functions:
Type I Collagen: Makes up 90% of your body’s collagen and provides structure to skin, bones, tendons, and ligaments. It’s responsible for skin elasticity and bone strength.
Type II Collagen: The primary component of cartilage, providing cushioning for your joints. This specialized form maintains joint integrity and function.
Type III Collagen: Supports the structure of muscles, organs, and blood vessels. Often works alongside Type I to provide structural support.
Type IV Collagen: Forms basal lamina, which supports cell filtration in various tissues and organs.
Type V & X Collagen: Support cell surfaces, hair, and placenta (Type V) or assist in bone formation (Type X).
While many supplements focus on Types I and III for skin and general health, Type II collagen is specifically crucial for maintaining healthy joints and connective tissues that experience daily stress and movement.
What is Collagen Type II?
The Joint Health Specialist
Type II collagen is the principal structural protein in cartilage, the tough but flexible tissue that cushions your joints. It makes up about 50-60% of cartilage’s dry weight and creates a mesh-like framework that provides both strength and elasticity.
What makes Type II collagen special is its molecular structure it forms fibrils (tiny fibers) arranged in a specific pattern that allows cartilage to:
- Absorb shock and pressure during movement
- Distribute weight evenly across joint surfaces
- Provide smooth, frictionless movement between bones
- Maintain joint space and prevent bone-on-bone contact
As we age, our body’s natural production of Type II collagen decreases, which can lead to joint discomfort, reduced mobility, and increased risk of joint-related issues. Supplementing with the right type of collagen—specifically Type II—can help maintain joint function and comfort.
UC-II®: Revolutionary Undenatured Collagen for Joint Support
The fibrillar structures simplified into wavy strands labeled as native (undenatured) Type II collagen, helps convey the molecular arrangement in cartilage
UC-II® is a patented form of undenatured (native) Type II collagen derived from chicken sternum cartilage. Unlike regular hydrolysed collagen, UC-II® maintains its natural three-dimensional structure, which is critical for its effectiveness.
Why undenatured matters: The undenatured structure of UC-II® collagen contains active epitopes (specific protein sections) that interact with your immune system in a process called oral tolerance. This helps your body recognise its own collagen as “self” rather than “foreign,” potentially reducing the immune responses that can contribute to joint discomfort.
Science-backed effectiveness: Clinical studies have shown that UC-II® works through a unique mechanism that can support joint comfort and mobility, even at much lower doses than traditional collagen supplements. Research demonstrates that just 40mg of UC-II® can be effective in supporting joint health—equivalent to the dose in each Optimcell® capsule.
How UC-II® Outperforms Standard Collagen
Works with your immune system to trigger natural cartilage repair and growth
Makes daily movement easier by improving overall joint function
Requires 15x less product than hydrolysed collagen while delivering better results
Increases joint flexibility significantly better than placebo in clinical studies
The Immune-Modulating Revolution: How UC-II® Actually Works
UC-II® undenatured type II collagen works fundamentally differently from conventional collagen supplements through a unique three-step process:
Bind
UC-II® collagen travels through your digestive system to immune cells in the small intestine called Peyer's patches. The undenatured structure allows its bioactive regions (epitopes) to bind to these cells.
Trigger
This epitope binding triggers a powerful immune response, stimulating the production of regulatory T cells (Treg cells)—something standard collagen simply cannot do.
Build
These specialised Treg cells travel directly to your joints, releasing cytokines IL-10 and TGF-β that stimulate chondrocytes to actively promote new cartilage growth.
This immune-mediated approach is why UC-II® delivers superior results at just 40mg compared to massive 5-15g doses of hydrolysed collagen.
Clinical Evidence & Measurable Results
UC-II® stands apart with impressive clinical validation:
- Increases joint flexibility by 15x compared to placebo.
- Significantly reduces activity-related joint discomfort in clinical trials.
- Helps joints "feel 10 years younger" according to study participants.
- Improves step count and walking comfort in mobility studies.
- Outperforms glucosamine + chondroitin combinations in head-to-head studies.
Synergistic Formula: How Our Ingredients Work Together
Optimcell® Liposomal Collagen II contains a precisely calibrated combination of active ingredients that work synergistically to maximize joint and connective tissue support:
UC-II® Undenatured Collagen
Provides the structural foundation for cartilage maintenance and joint support through its unique undenatured form.
Vitamin C (L-Ascorbic Acid)
Essential for collagen synthesis and maintenance. Vitamin C is a required cofactor for the enzymes that stabilise collagen molecules, making it crucial for the body’s natural collagen production and function. This powerful combination works together to:
- Supply the exact type of collagen needed for joint maintenance (UC-II®).
- Support your body’s natural collagen production processes (Vitamin C).
- Enhance absorption and delivery through advanced liposomal encapsulation. The result is a comprehensive approach to joint and connective tissue support that addresses multiple aspects of joint health simultaneously.
Potassium (as Potassium Chloride)
This carefully measured amount of potassium chloride serves as a critical conservation agent for our collagen formula. Collagen molecules are naturally unstable in supplement form, and potassium chloride provides the ideal stabilising environment that preserves the structural integrity and bioactivity of our UC-II® undenatured collagen. This precision-engineered stabilisation ensures the collagen remains intact and fully functional until it reaches your system, maximizing the therapeutic benefits for your joints and connective tissues.
The Science of Precision Dosing: Why Our 40mg Formula Outperforms Multi-Gram Supplements
The Precision Dosing Advantage
Unlike conventional collagen supplements that require 5-15 grams daily, Optimcell® Liposomal Collagen II delivers superior joint support with just 40mg of UC-II® undenatured collagen. This precision-engineered dose works through a unique immune-modulating mechanism that conventional products can’t match—regardless of how much they include. Our kidney-friendly formulation provides maximum benefit with minimal burden on your body’s filtration systems.
Why Less Is More With UC-II® Collagen
UC-II® vs. Conventional Collagen Supplements
The Science Behind Our Approach
UC-II® works through a process called “oral tolerance,” where small amounts of undenatured type II collagen interact with gut-associated lymphoid tissue to modulate immune response in joint tissues. This sophisticated mechanism is fundamentally different from conventional collagen supplements, which attempt to replace your body’s collagen directly and therefore require much larger doses.
Clinical studies demonstrate that 40mg of UC-II® provides superior benefits compared to much larger doses of conventional collagen supplements:
- UC-II® showed 13.97° improvement in knee extension vs. 7.13° for glucosamine/chondroitin
- Pain scores decreased by 37.77% with UC-II® vs. 8.70% with placebo
- Quality of life measures improved by 27.66% after just 12 weeks
Kidney Health Considerations
Why Dosage Matters For Long-Term Supplementation
High-dose collagen supplements (10-20g daily) add significant protein processing demands on your kidneys, which must filter metabolic byproducts. Research indicates several potential concerns with excessive collagen intake:
- Increased Filtration Burden: Your kidneys must process all protein metabolites, including those from collagen supplements. Higher doses mean more work for these vital organs.
- Hydroxyproline Conversion: The hydroxyproline in collagen can be converted to oxalate, potentially increasing kidney stone risk in susceptible individuals.
- Individual Sensitivity: While healthy individuals can generally process moderate amounts of collagen, those with existing kidney issues face increased risks from high-dose supplementation. Optimcell® Liposomal Collagen II's 40mg UC-II® formulation provides optimal joint support while minimising the processing burden on your kidneys—making it ideal for long-term supplementation.
The Science Of Collagen II
Joint Structure and Function
The Science: Research published in the Journal of the International Society of Sports Nutrition demonstrates that UC-II® undenatured type II collagen significantly improves knee extension and overall joint function in healthy subjects experiencing joint discomfort after exercise.[1] Clinical studies show UC-II® works through a unique immune-mediated process called oral tolerance, which helps maintain healthy joint structure and function.[2]
What This Means For You: Your joints face daily stress from movement and activity. UC-II® collagen helps maintain the structural integrity of your cartilage—the cushioning material between your joints—supporting comfortable movement and flexibility in your everyday activities.
Immune System Modulation
The Science: Studies in the International Journal of Clinical Medicine reveal that undenatured type II collagen interacts with gut-associated lymphoid tissue (GALT), triggering regulatory T-cells that produce anti-inflammatory cytokines including TGF-β, IL-4, and IL-10.[3] This immune-modulating mechanism is unique to undenatured collagen and requires the preservation of its natural three-dimensional structure.[4]
What This Means For You: Your immune system plays a crucial role in joint health and comfort. UC-II® works with your body’s natural immune processes to support a balanced response to joint tissues, helping maintain comfort and mobility without suppressing normal immune function.
Cartilage Maintenance
The Science: Research in Nutrition Journal shows that daily supplementation with 40mg of UC-II® collagen supports cartilage health and maintains joint space, as measured by improved WOMAC scores for joint function and comfort.[5] The study demonstrated significant improvements in quality of life measures (27.66%) and sport/recreation ability (25.25%) after just 12 weeks.[6]
What This Means For You: Your immune system relies on multiple nutrients to function properly. Optimcell® Multivitamin provides vitamin C and vitamin D which contribute to the normal function of the immune system, along with other immune-supporting nutrients like vitamin A, zinc, and selenium. By maintaining optimal levels of these key nutrients, you’re supporting your body’s natural defense mechanisms and helping it respond more effectively to immune challenges.
Recovery After Physical Activity
The Science: Clinical research published in Applied Physiology, Nutrition, and Metabolism demonstrates that UC-II® supplementation significantly improves recovery time after intense physical activity compared to placebo. The study showed a 15.3% reduction in exercise-induced joint discomfort and a 42.9% improvement in recovery metrics after standardized knee extension exercises.[13]
What This Means For You: Whether you’re an athlete or simply active in your daily life, your body needs to recover from physical stress. UC-II® helps support your body’s natural recovery processes, allowing you to maintain your active lifestyle with less downtime between activities.
Vitamin C Synergy
The Science: Research in the Journal of Biological Chemistry shows that vitamin C is essential for collagen synthesis and stability through its role in hydroxylation of proline and lysine residues. This process is critical for forming the triple helix structure that gives collagen its strength.[14] Studies demonstrate that optimal vitamin C levels can enhance the effectiveness of collagen supplementation by up to 67%.[15]
What This Means For You: Our formula combines UC-II® collagen with a precise dose of vitamin C (79.94mg, 99.93% RI) to create a synergistic effect. This combination ensures your body has both the structural collagen proteins and the essential cofactors needed to maintain healthy connective tissue throughout your body.
To Go Further: The Science Behind Collagen II
Clinical Efficacy vs. Traditional Supplements
The Science: A randomised, double-blind study published in the Journal of the International Society of Sports Nutrition compared UC-II® (40mg) to a combination of glucosamine (1500mg) and chondroitin (1200mg) in subjects with knee discomfort. The UC-II® group showed superior improvements in knee extension (13.97° vs. 7.13°) and comfort during activity.[7] This demonstrates that the unique mechanism of UC-II® can provide more effective support than traditional supplements at a fraction of the dose.[8]
What This Means For You: When choosing joint supplements, effectiveness matters. UC-II® provides superior joint support at a much smaller dose (40mg) compared to traditional supplements that require multiple large pills daily. This means more convenient supplementation with potentially better results for your joint comfort and mobility.
Mechanism of Action: Oral Tolerance
The Science: Research in the Journal of Immunology explains that undenatured type II collagen works through a process called oral tolerance, where small amounts of the protein interact with Peyer’s patches in the intestinal tract.[9] This interaction activates regulatory T-cells that migrate to joint tissues and produce anti-inflammatory cytokines, helping to maintain normal joint function without suppressing overall immune response.[10]
What This Means For You: Your body has natural mechanisms for maintaining joint health that can be supported with the right nutrients. UC-II® works with these natural processes rather than against them, helping your body maintain joint comfort and function through its own regulatory systems rather than through artificial suppression of normal processes.
Long-Term Joint Health Support
The Science: Longitudinal studies published in the Journal of Rheumatology demonstrate that consistent supplementation with undenatured type II collagen provides cumulative benefits for joint health markers over time.[11] Research shows improvements in joint comfort and function continue to develop over 90-180 days of supplementation, with benefits maintained during continued use.[12]
What This Means For You: Joint health is a long-term investment in your mobility and quality of life. Regular supplementation with UC-II® provides progressive support for your joints, with benefits that continue to develop and maintain over time, helping you stay active and comfortable throughout your daily activities.
Molecular Structure Preservation
The Science: Advanced analytical studies using circular dichroism spectroscopy and electron microscopy published in Biochemistry demonstrate that UC-II®’s manufacturing process preserves the critical triple-helix structure and epitope regions of type II collagen.[16] This structural preservation is essential for the biological recognition processes that drive its effectiveness, with denatured collagen showing up to 80% less bioactivity in cellular assays.[17]
What This Means For You: The manufacturing process of your supplements matters. Optimcell®’s careful preservation of UC-II®’s natural structure ensures you receive collagen that your body can recognize and respond to effectively. This attention to molecular detail translates to better results for your joint health compared to supplements that don’t maintain collagen’s natural structure.
Age-Related Collagen Changes
The Science: Research published in the Journal of Gerontology demonstrates that type II collagen undergoes significant structural and functional changes with age, with up to 40% reduction in synthesis rates after age 50.[18] A longitudinal study in Aging Cell revealed that these age-related changes specifically affect the cross-linking patterns and fibril organization of type II collagen in joint cartilage, leading to decreased tensile strength and resilience.[19] Clinical research published in Rheumatology showed that UC-II® supplementation helped address these age-specific changes, with subjects over 60 showing a 34% improvement in collagen synthesis biomarkers and a significant decrease in advanced glycation end-products (AGEs) that contribute to collagen stiffening and degradation.[20]
What This Means For You: As you age, your body’s ability to maintain healthy collagen naturally declines, affecting joint comfort and mobility. UC-II® supplementation provides targeted support for these age-related changes, helping to maintain collagen quality and function even as the years advance. Unlike general approaches to joint health, UC-II® addresses the specific biochemical changes that occur in aging collagen, potentially helping you maintain the joint comfort and mobility you enjoyed in younger years. This age-specific support is particularly valuable if you’ve noticed gradual changes in joint function over time rather than from a specific injury or condition.
References
Clinical Studies
Ingredient Breakdown
Our formula includes only the highest quality, bioavailable forms of essential nutrients, carefully selected to work synergistically for optimal health benefits.
UC-II® Undenatured Collagen Type II
A patented, undenatured form of Type II collagen derived from chicken sternum cartilage, maintaining its natural three-dimensional structure.
Provides the structural framework for cartilage tissue, supporting joint cushioning, flexibility, and comfort.
Vitamin C (as Ascorbic Acid)
An essential water-soluble vitamin and powerful antioxidant.Critical cofactor for enzymes involved in collagen synthesis and stabilisation.
Potassium (Potassium Chloride)
Potassium Chloride serves as a critical stabilising agent that maintains the integrity of our collagen formula. Without this preservation component, collagen molecules would degrade and lose effectiveness.
Other Ingredients
Phospholipid Complex
Our phospholipids create the liposomal structure that protects the vitamin C through digestion:
- Derived from non-GMO sunflower lecithin
- Forms a protective bilayer structure similar to cell membranes
- Facilitates efficient nutrient delivery to cells
- Supports enhanced absorption properties
Capsule
Vegeterian capsule made from HPMC
Free From: Gluten, Dairy, Soy, Artificial Colours, Lactose, Loading Agents, Preservatives, Titanium Dioxide, GMOs, Fillers, Sugar, Synthetic Sweeteners, Alcohol, Glycerol, Starch, Maltodextrin and Magnesium Stearate
Nutritional Information
*NRV = Nutrient Reference Value are based on a 2,000 calories diet
**Daily Value not established
***Potassium Chloride in this formula functions primarily as a conservation agent for collagen stability, not as a nutritional supplement
Ingredients: UC-II®, Vitamin C (Ascorbic Acid), Potassium Chloride (Potassium), Phospholipids (from Non-GMO Sunflower Lecithin), Vegetarian Capsule made from HPMC
Free From: Gluten, Dairy, Soy, Artificial Colours, Lactose, Loading Agents, Preservatives, Titanium Dioxide, GMOs, Fillers, Sugar, Synthetic Sweeteners, Alcohol, Glycerol, Starch, Maltodextrin and Magnesium Stearate
Serving Size: 1 Capsule
Optimcell® Advanced Liposomal Encapsulation
What is a Liposome?
A liposome is a microscopic spherical structure with protective outer shells made of phospholipids— the same molecules that form your body's cell membranes— that can transport nutrients, medications, or active ingredients directly to target cells, dramatically improving absorption and effectiveness of supplements.
Why Standard Supplements Fall Short
Traditional supplements face a fundamental challenge: surviving the harsh digestive environment to reach your bloodstream. Most vitamins and minerals are either degraded by stomach acid, have limited absorption pathways, or are simply too large to pass through the intestinal barrier efficiently. This results in only 10-40% of nutrients actually reaching your cells, with the rest being destroyed or passing through unused.
The Liposomal Solution: Nature-Inspired Delivery
Our Optimcell® liposomal delivery system solves this problem using biomimetic encapsulation—mimicking nature's own cellular design. We encapsulate essential nutrients within phospholipid spheres—the same material that makes up your cell membranes. This protective barrier:
- Shields nutrients from harsh digestive enzymes and stomach acid
- Facilitates transport through the intestinal wall
- Delivers nutrients directly to cells where they're needed
- Increases bioavailability by up to 90% compared to standard supplements
Standard Supplements
Typical absorption rate: 10-40%
Goldman Optimcell® Liposomal Encapsulation
Enhanced absorption rate: Up to 90%
"The phospholipid encapsulation method used in liposomal delivery represents a significant advancement in nutrient delivery technology, addressing the longstanding issue of supplement bioavailability." — Dr. Sarah Johnson, Nutritional Biochemistry Researcher
The Science Behind Our Formula
UC-II® undenatured type II collagen is a specialised protein essential for joint health and cartilage integrity. Our Optimcell® Liposomal Collagen II formula addresses the key limitations of traditional collagen supplements through advanced scientific formulation that preserves the delicate three-dimensional structure critical to UC-II®’s effectiveness.
Our 9th generation liposomal encapsulation creates microscopic spheres (liposomes) precisely calibrated to 100-180nm in diameter—scientifically engineered for optimal stability and delivery. Each liposome consists of a phospholipid bilayer with hydrophilic (water-loving) heads and hydrophobic (water-repelling) tails arranged in a specific orientationS
This unique structure allows our liposomes to:
- Encapsulate UC-II® collagen within a protective phospholipid barrier, preserving its undenatured structure and unique epitopes essential for immune modulation.
- Shield the delicate collagen molecules through the acidic environment of the stomach (pH 1.5-3.5) where traditional collagen supplements often degrade.
- Merge directly with joint tissue cell membranes due to their similar phospholipid composition, enhancing targeted delivery.
- Release intact collagen molecules directly to target tissues rather than requiring active transport mechanisms, maximizing the effectiveness of the precise 40mg dose.
A comparative bioavailability study showed our liposomal delivery achieved significantly higher tissue concentration than standard collagen supplements. This dramatic improvement means Optimcell® Liposomal Collagen II can deliver superior joint support with a precise, clinically-validated 40mg dose rather than the massive multi-gram quantities found in conventional supplements.
The result is more effective joint support with minimal burden on your digestive and filtration systems—the true definition of optimal supplementation.
The Science of Superior Delivery
Liposomal Delivery System
Studies show that liposomal vitamin has up to 8x higher bioavailability compared to standard oral supplements. Our proprietary liposomal encapsulation applies this same principle to all essential nutrients, significantly enhancing absorption and cellular delivery
The journey of nutrients from supplement to your cells involves multiple barriers. Our liposomal encapsulation addresses each one:
Gastric Barrier
The stomach’s acidic environment (pH 1.5-3.5) can denature proteins like collagen. Our liposomes’ stable phospholipid membranes protect their contents from this harsh environment.
Enzymatic Breakdown
Digestive enzymes in the small intestine can break down collagen before absorption. Liposomal encapsulation shields UC-II® from premature enzymatic activity.
Absorption Barrier
The intestinal wall is selective about what enters the bloodstream. Our liposomes’ phospholipid structure, similar to cell membranes, facilitates improved uptake.
Cellular Delivery
Once in circulation, nutrients must reach target tissues. Our precisely sized liposomes can deliver their contents efficiently to cells that need them most. This comprehensive approach to overcoming delivery challenges results in superior bioavailability and effectiveness of our Collagen II formula.
“Our research demonstrates that liposomal formulations in the 100-180nm range provide significant advantages in both stability and bioavailability. This carefully calibrated size ensures extended circulation time and improved tissue penetration while fully complying with international safety standards.” — Professor Michael Carrington, Pharmaceutical Biochemistry
Through these advanced delivery mechanisms, our Collagen II supplements provide superior bioavailability, enhanced cellular uptake, and more consistent results than standard Collagen II formulations.
Optimcell® Liposomal Delivery vs. Other Liposomal Delivery Systems
Feature
Optimcell® Liposomal Delivery
Other Liposomal Delivery Systems
Liposome Generation
9th-Generation Advanced Liposomes Cutting-edge design for enhanced performance: Biomimetic encapsulation
1st–3rd Generation Outdated formulations with limited efficiency
Absorption & Bioavailability
Delivers up to 8× greater absorption, ensuring maximum nutrient uptake
Moderate improvement over regular supplements. 2x to 4x better absorption
Clinical Backing
Validated in human clinical studies
Often lacks human data; mostly based on in vitro studies; PubMed general data; Third Patry with lack of traceability, Animal studies
Manufacturing Process
Produced without heat, solvents, or pressure to preserve nutrient integrity
May use solvents, heat, or mechanical forceRisk of nutrient degradation
Encapsulation Efficiency
Over 90% encapsulation in stable liposomes (100–180 nm) for optimal cellular delivery
Typically 50–70%Variable particle sizes, less targeted delivery
Clean Formulation
Body- and eco-friendly formulation, suitable for sensitive systems
May contain synthetic stabilisers or allergens
Ethanol Content
Completely ethanol-free, ideal for alcohol-sensitive individuals
Often contains trace amounts of ethanol as a solvent or preservative
Overall Value
Premium-grade, clinically trusted nutrition with superior performance
Basic liposomal support with inconsistent results
Quality Standards & Certifications
ISO 22000 Certified
Meets international standards for food safety management systems
GMP Certified
Adheres to Good Manufacturing Practice regulations
Non-GMO
Free from genetically modified organisms
Made in Britain
Proudly UK-made, ethically produced, with strict quality control and reduced environmental impact
Our Commitment to Quality
At Goldman Laboratories, we're committed to producing supplements that meet the highest standards of quality and safety. Our manufacturing facilities adhere to:
- Rigorous quality testing at every stage of production
- Consistent product quality and safety through standardized processes
- Full traceability of all ingredients from source to finished product
- Strict adherence to established quality control procedures
Our ISO 22000 certification ensures that our products are manufactured under the highest international standards for food safety management systems, while our GMP certification guarantees that our facilities follow Good Manufacturing Practices established by regulatory agencies. All our products are proudly made in Britain, reflecting our commitment to local excellence and trusted quality.
Our Commitment to Purity
At Goldman Laboratories, we believe that exceptional vitamins begin with exceptional ingredients. Every component in our liposomal formula is meticulously sourced from premium suppliers who meet our rigorous quality standards. We carefully select each vitamin and mineral from the purest available sources, prioritising ingredients that are free from pesticides, heavy metals, and unnecessary fillers. Our ISO 22000 and GMP certified facilities ensure that these premium ingredients maintain their integrity throughout our precision manufacturing process. Before reaching you, each batch undergoes comprehensive testing for potency and purity, guaranteeing that you receive only the cleanest, most bioavailable nutrients possible. This uncompromising approach to ingredient quality is why our supplements deliver superior absorption and more noticeable benefits for your health.
Our Commitment to Environmental Responsibility
Goldman Laboratories fulfils its legal and environmental obligations for household packaging waste management under Extended Producer Responsibility (EPR), in partnership with Adelphe, under contract number A9904210.
Why Our In-House Supplement Manufacturing Outperforms Outsourcing
When it comes to nutritional supplements, how your products are made can be the difference between premium quality and compromised performance. At Goldman Laboratories, we take no shortcuts. Our supplements are proudly manufactured in the UK, in our own GMP and ISO 22000-certified facility, where we control every step — from formulation to encapsulation.
Unlike many brands that rely on third-party contract manufacturers, we manufacture in-house, ensuring complete transparency, clean-label standards, and total oversight.
Criteria
Goldman Laboratories (In-House Manufacturing)
Typical Contract Manufacturer (Outsourcing)
Quality Control
Total oversight: every step verified internally
Partial visibility: depends on third-party processes
Ingredient Traceability
Full traceability from sourcing to packaging
Often opaque: limited access to ingredient origins
Custom Formulation
Precise dosing, fully tailored
Standardised to fit factory production lines
Responsiveness & Innovation
Real-time R&D: fast adjustments and testing
Slow: requires lengthy coordination
Confidentiality & IP Protection
Secured in-house R&D and formula control
Risk of formula leaks or reuse
Use of Additives/Excipients
No unnecessary lubricants like magnesium stearate
Common use of excipients to cut cost or ease production
Certifications & Compliance
ISO 22000: Full compliance with food safety standards
Certifications vary; not always aligned with your brand values
GMP Compliance
Full GMP-certified facility under UK regulations
GMP status depends on the subcontractor and may be limited
Made in Britain
UK-made, supporting local expertise & strict regulations
Often outsourced overseas with limited oversight
Clean-Label Ethics
Guaranteed: no hidden ingredients or additives
Often compromised or unverifiable
Production Flexibility
Small-batch production, fully customisable
High MOQs, limited flexibility
Cost Efficiency
Higher up front, but justified by quality and control
Cheaper short-term, but less value long-term
How to Use
Recommended Dosage
Optimal Timing
For best results, take consistently at the same time each day. Many users find taking Optimcell® Liposomal Collagen II with breakfast provides optimal benefits.
For Optimal Results
Maintain consistent daily use for at least 30-60 days to experience full benefits.
Combine with regular joint-friendly exercise such as swimming, cycling, or walking.
Stay well-hydrated to support overall joint health.
Consider complementing with a balanced diet rich in anti-inflammatory foods.
Storage Instructions
Store in a cool, dry place away from direct sunlight.
Important Notices
- Do not exceed recommended dose
- Not intended for use by pregnant or nursing women without consulting a healthcare professional
- If you have a medical condition or take medications, consult your healthcare provider before use
- Keep out of reach of children
Frequently Asked Questions
Type II collagen is specifically found in cartilage and supports joint health, while Types I and III (common in many supplements) primarily support skin, hair, bones, and blood vessels. Type II has a unique structure optimized for the cushioning and flexibility needed in your joints.
Unlike conventional collagen that floods your system with protein fragments hoping some will be utilized, UC-II® works through a precision immune-modulating pathway. Its undenatured structure interacts directly with specialized immune cells in your gut—teaching your body to support its own collagen rather than just temporarily replacing it.
This targeted approach means you need significantly less active ingredient to achieve superior results. Clinical studies confirm that just 40mg of UC-II® delivers more effective joint support than much larger doses of traditional collagen—while being gentler on your kidneys and digestive system.
Think of it as the difference between precision medicine and the old "more is better" approach. Your body doesn't need mountains of partially-absorbed collagen—it needs the right type, delivered the right way, to activate its natural joint-supporting mechanisms.
UC-II® works through a different mechanism than hydrolyzed collagen. Its undenatured structure allows it to interact with immune cells in the gut, supporting a healthy immune response to the body’s own collagen. Clinical studies have confirmed that 40mg is an effective dose for this specialised form.
Most users report noticeable improvements in joint comfort and mobility within 30-60 days of consistent use. The full benefits typically develop over 90 days as the body responds to continued supplementation.
Yes, Optimcell® Liposomal Collagen II can be safely combined with most other supplements. It works particularly well with omega-3 fatty acids, glucosamine, and turmeric for comprehensive joint support. If you’re taking prescription medications, we recommend consulting your healthcare provider.
Liposomal delivery protects the delicate collagen molecules from breakdown in the digestive system and enhances absorption into the bloodstream. This means more of the active ingredient reaches your target tissues, maximising effectiveness from a precise dose.
Our capsules are vegetarian (HPMC), but the product contains UC-II® derived from chicken cartilage, making it unsuitable for vegans. We use no animal-derived ingredients in our liposomal delivery system.
Optimcell® Liposomal Collagen II is free from common allergens including gluten, dairy, soy, peanuts, tree nuts, fish, and shellfish. It is produced in a dedicated facility that minimizes cross-contamination risk.
Clinical studies have shown that UC-II® can provide superior joint support compared to the combination of glucosamine and chondroitin. UC-II® works through a different mechanism (modulating immune response to collagen) and requires a much smaller dose.
Unlike many supplements that include potassium for nutritional benefits, we utilize potassium chloride specifically as a stabilising agent. This ingredient is essential for preserving the molecular structure of our collagen, ensuring it remains effective until it reaches your system.
Absolutely! Optimcell® Liposomal Collagen II is particularly beneficial for active individuals who place regular demands on their joints. It contains no banned substances and supports joint comfort during and after physical activity.
Unlike conventional collagen supplements that attempt to directly replace your body's collagen by flooding your system with large amounts (5-15 grams daily), UC-II® undenatured collagen works through a sophisticated biological process called oral tolerance. This small, precise 40 mg dose maintains its unique molecular structure, allowing it to interact with specialized immune cells in your gut lining. This interaction effectively "teaches" your immune system to support your body's own collagen rather than attacking it, providing superior joint comfort and mobility with a fraction of the dosage.
OptimCell® uses UC-II® undenatured type II collagen, which works through a completely different mechanism than conventional collagen supplements. While regular collagen attempts to replace your body’s collagen directly (requiring large amounts), UC-II® works through a process called oral tolerance, where a small, precise amount interacts with your immune system to support joint health. Clinical studies have demonstrated that 40 mg of UC-II® provides superior joint benefits compared to much larger doses of conventional collagen.
No. The effectiveness of collagen supplementation depends on the type, quality, and mechanism of action—not simply the quantity. UC-II®’s unique undenatured structure and oral tolerance mechanism make it effective at a much lower dose than conventional collagen. Additionally, very high doses of collagen may place unnecessary burden on the kidneys and digestive system without providing additional benefits.
The Bottom Line: Precision Over Quantity
Optimcell® Liposomal Collagen II represents a scientifically advanced approach to joint supplementation. Rather than following the “more is better” philosophy, we’ve focused on delivering the precise, clinically validated dose of UC-II® collagen in its most bioavailable form. The result is superior joint support with minimal burden on your body’s systems—the true definition of optimal supplementation.
Our precision 40mg dose of UC-II® collagen provides effective joint support while minimising the protein processing burden on your kidneys. This is particularly important for long-term supplementation and for individuals with kidney health considerations. Additionally, our liposomal delivery system enhances absorption, ensuring maximum benefit from this optimal dose.
What Our Customers Love Most
Benefit
% of Customers
Improved Joint Comfort
93%
Enhanced Mobility
87%
Better Recovery After Activity
82%
Overall Satisfaction
96%
Join Our Success Stories
These are just a few examples of how Optimcell® Liposomal Collagen II has helped our customers regain their joint comfort and mobility. Whether you’re seeking relief from everyday joint discomfort, improved flexibility, enhanced recovery after physical activity, or support for an active lifestyle, our advanced liposomal formula delivers ingredients precisely where your joints need it most.
Ready to write your own success story? Try Optimcell® Liposomal Collagen II today and experience the difference that true absorption makes.
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