Understanding CoQ10 brain health is vital at the time you think about that the brain uses up about 20% of the body's energy despite making up only 2% of body weight . People age and CoQ10 levels decline. This reduction brings decreased mental sharpness and stamina . Learning about CoQ10 to support brain health has gained most important attention, especially among those over 55. This piece gets into whether CoQ10 is good for brain health and reviews the CoQ10 benefits supported by science. We also provide guidance on supplementation.
Key Takeaways
Understanding CoQ10's role in brain health becomes essential after 55, when natural production declines and cognitive energy demands remain high.
• CoQ10 levels drop by approximately 50% between ages 25-65, particularly affecting brain tissue which consumes 20% of the body's total energy despite being only 2% of body weight.
• Supplementation with 100-200mg daily may reduce mental fatigue, protect against oxidative stress, and support memory function, with ubiquinol showing superior absorption in older adults.
• Clinical evidence remains mixed, but animal studies consistently show cognitive improvements, suggesting CoQ10 may help maintain brain energy production when natural synthesis declines.
• Take CoQ10 with fatty meals in the morning for optimal absorption, and combine with Mediterranean-style diet, regular exercise, and quality sleep for maximum brain health benefits.
• Adults taking statins or experiencing mental fatigue should particularly consider CoQ10 supplementation, as these medications can further reduce already declining natural levels.
CoQ10 represents one valuable tool in a comprehensive approach to cognitive health after 55, working best when integrated with other brain-supporting lifestyle practises rather than as a standalone intervention.
What Is Coenzyme Q10 and Why Does Your Brain Need It?
The role of CoQ10 in cellular energy production
Coenzyme Q10 exists as a vitamin-like substance that the body produces naturally, though by definition it's not a vitamin since human tissues can synthesise it themselves [1]. This lipid-soluble compound sits within the inner mitochondrial membrane and performs functions critical to cellular survival.
CoQ10 acts as an electron carrier in the mitochondrial electron transport chain. It accepts electrons from complex I and complex II, then transfers them to complex III [1][1]. This electron movement creates a proton gradient across the inner mitochondrial membrane. ATP gets generated when protons flow back. This chemical energy powers every cellular process [1].
This energy production system falters without adequate CoQ10. The body just needs about 500 mg of CoQ10 daily from both internal production and dietary sources, based on total body stores of about 2 mg and an average turnover time of 4 days in tissue [1]. Ninety-five percent of human energy generation depends on this mitochondrial process [2].
CoQ10 exists in two interchangeable forms: ubiquinone (oxidised) and ubiquinol (reduced) [1]. The molecule cycles between these states as it transports electrons. The reduced ubiquinol form provides the antioxidant protection that shields mitochondrial membranes from oxidative damage [1]. This dual role makes CoQ10 unique. It drives energy production and defends cells against the reactive oxygen species that energy generation creates.
How CoQ10 supports brain function
The brain's extraordinary energy demands make CoQ10 vital for neural health. Abnormal mitochondrial function reduces energy availability in brain cells, which can contribute to neurological problems [1]. Mitochondrial dysfunction appears as a common factor in neurological disorders like Parkinson's disease and Alzheimer's disease [1].
Research has identified CoQ10 deficiency in brain tissue from patients with these conditions. Studies found reduced CoQ10 levels in cerebral cortex samples from Parkinson's patients and cerebellar tissue from multiple system atrophy patients [1]. The connection between mitochondrial health and cognitive function extends beyond disease states to normal ageing processes.
CoQ10 serves brain cells through multiple mechanisms. As an antioxidant, it neutralises free radicals that cause cellular damage [3]. This protection proves important in neural tissue, where oxidative stress guides neuronal death and cognitive decline. The brain's high metabolic rate generates substantial oxidative stress and requires reliable antioxidant defences.
Oral CoQ10 supplementation increases brain mitochondrial concentrations by about 30%. This restores levels like those seen in younger animals [1]. Supplementation increased cerebral cortex CoQ10 from 68.6 ng/mg to 74.4 ng/mg of protein in aged rats [1]. These increases demonstrate that exogenous CoQ10 can reach brain tissue and support cellular energy pathways, though the exact mechanism by which it crosses the blood-brain barrier requires further study [1].
Where CoQ10 is found in the body
CoQ10 appears in cell membranes throughout the body. Distribution reflects metabolic activity and energy requirements [1]. The highest concentrations exist in organs with the most important energy demands: heart, liver, kidney, and pancreas [1][2].
About 50% of total CoQ10 resides in mitochondria within cells. The remainder distributes across other subcellular structures like the endoplasmic reticulum and Golgi apparatus [1]. The mitochondrial concentration exceeds other respiratory chain components by roughly tenfold [2].
CoQ10 concentrations change throughout the lifespan. Levels increase during early life and peak around the mid-twenties when biosynthesis reaches its optimum. They then decline with age [2][1]. This age-related reduction occurs across different tissues, though whether it constitutes a true deficiency remains unclear [1]. Decreased plasma CoQ10 has been observed if you have diabetes, cancer, and heart failure [1].
The body produces most of its CoQ10 internally. Dietary intake contributes small amounts, typically 3-5 mg daily [2]. Meat, fish, nuts, and certain oils provide the richest food sources. Dairy products, vegetables, fruits, and cereals contain much lower levels [2].
How CoQ10 Levels Change After Age 55
Natural decline in CoQ10 production with age
The body's knowing how to make CoQ10 reaches its peak around 25 years of age. Production diminishes after that [1]. This decline shows up differently in tissues of all types. CoQ10 production at age 65 drops to about half the levels measured at age 25 in heart tissue [1]. Research in human tissues has identified the highest CoQ10 values at 20 years of age. Reductions occur as part of the normal ageing process after that [1].
The pattern of decline proves more complex than a simple downward trajectory. Blood plasma CoQ10 levels increase from young adulthood through middle age and peak around age 60 before beginning a slight decrease [1]. This blood measurement contrasts sharply with what occurs in brain and heart tissue, where CoQ10 levels decrease with age [1]. The difference matters because tissue levels reflect the CoQ10 available for cellular energy production. Blood levels may not represent what's happening inside organs.
After age 60, another move occurs. The body becomes less efficient at converting CoQ10 into its active form, ubiquinol [1]. This conversion inefficiency compounds the existing production decline and reduces the amount of bioactive CoQ10 available for mitochondrial function and antioxidant protection. Certain medications accelerate this decline further. Statins, prescribed to elderly patients for cholesterol management, may inhibit endogenous CoQ10 synthesis [1]. Chronic diseases associated with ageing also associate with lower CoQ10 levels in tissues and organs [1].
Animal studies reveal that CoQ10 reduction during ageing varies by tissue type. Some research showed decreased levels in heart, kidney, and skeletal muscles in older rats. Liver levels increased and brain and lung managed to keep constant concentrations [1]. Other studies showed a direct association between CoQ10 decline and ageing in specific rat brain areas [1]. At present, no comparable data exists for changes in CoQ10 levels in the human brain as a function of normal ageing [1].
Why the brain is affected especially
Neural tissue proves vulnerable to CoQ10 deficiency because of the brain's extraordinary energy requirements. Normal brain function demands energy equivalent to 20% of total body energy consumption [1], despite the brain representing only a small fraction of body weight. This metabolic intensity makes adequate mitochondrial function non-negotiable for cognitive performance.
The brain contains high amounts of CoQ10 under normal circumstances [4] and reflects this lifted energy demand. Mitochondrial dysfunction follows when CoQ10 levels drop and compromises the brain's knowing how to generate sufficient ATP. This energy deficit affects multiple aspects of neural function, from neurotransmitter synthesis to cellular repair processes.
Age-related depletion of tissue CoQ10 levels parallels the increased risk of developing neurological disorders [1]. CoQ10 deficiency triggers apoptosis in tissues of the central nervous system on a cellular level [5]. This programmed cell death contributes to the neural deterioration observed in various age-related conditions. Oxidative stress intensifies as antioxidant defences weaken and creates a cycle where reduced cellular energy production and increased oxidative damage reinforce each other.
Mitochondrial dysfunction and oxidative stress represent major contributors to cognitive decline and neurodegenerative diseases [5]. CoQ10's dual role in energy production and antioxidant protection positions it as a critical factor in maintaining brain health after 55. The reduction in CoQ10 biosynthesis that occurs during ageing appears to affect neurological function more severely than other body systems [1].
Signs your brain may just need more CoQ10
Cognitive symptoms may point to insufficient CoQ10 levels in brain tissue. Low CoQ10 shows as confusion and cloudy thinking [4] and reflects the brain's struggle to maintain normal function without adequate energy production. Mental fatigue often emerges as an early sign, different from physical tiredness.
Additional indicators include reduced mental stamina throughout the day, difficulty concentrating on complex tasks, and slower information processing. These symptoms overlap with general ageing effects and make them easy to dismiss. But the underlying mechanism is different. Normal ageing involves changes across multiple systems. CoQ10 deficiency impairs mitochondrial energy production.
The challenge lies in distinguishing CoQ10-related cognitive changes from other age-associated factors. No simple diagnostic test measures brain tissue CoQ10 levels. Blood tests reveal plasma concentrations, yet these may not reflect what's occurring in neural tissue. Individuals taking statins or those with chronic diseases face lifted risk for CoQ10 depletion and should monitor cognitive function with care.
CoQ10 Benefits for Brain Health After 55
Improved mental energy and reduced fatigue
Fatigue reduction represents one of the most prominent CoQ10 benefits for brain health in older adults. A meta-analysis that scrutinised 13 randomised controlled trials with 1,126 participants found that CoQ10 supplementation produced a reduction in fatigue scores that was statistically significant compared to placebo groups [6]. The effect proved consistent in both healthy people and those with fatigue-associated diseases.
The research showed that increases in daily CoQ10 dose and treatment duration related to greater fatigue reduction [6]. Studies using straight CoQ10 supplements showed stronger results than combination formulas, likely due to higher CoQ10 concentrations in single-ingredient products [6]. CoQ10 supplementation improved cognitive function, reduced fatigue symptoms, and improved working memory and arithmetic task performance in patients with chronic fatigue syndrome [1].
The mechanism behind this mental energy boost stems from CoQ10's role in ATP synthesis. Preoperative CoQ10 therapy at 300 mg daily lifted myocardial and cardiac mitochondrial CoQ10 levels and improved the efficiency of mitochondrial energy production [1][1]. Multiple sclerosis patients who received 500 mg daily experienced improvements in both depression and fatigue [5].
Protection against oxidative stress
CoQ10 serves as a lipid-soluble antioxidant that protects mitochondrial membranes from free radical-induced oxidative stress [7]. This protection proves relevant after 55 when oxidative damage accumulates in brain tissue. The brain's vulnerability stems from its high oxygen consumption and lipid content, making it susceptible to oxidative damage over time.
Animal studies reveal CoQ10's effectiveness in reducing oxidative markers. CoQ10 administration reduced thiobarbituric acid reactive substances and lifted antioxidant enzyme activity in brain tissue in rats with Alzheimer's-type pathology [5]. CoQ10 reversed increases in serum malondialdehyde levels and total oxidative stress in rats injected with beta-amyloid [8]. CoQ10 supplementation at 60-150 mg daily reduced inflammatory cytokines in human serum [5][9].
The antioxidant function derives from CoQ10's reduced ubiquinol form [5]. CoQ10 scavenges free radicals and inhibits apoptotic death caused by reactive oxygen species while increasing cellular antioxidant capacity [5][9]. Supplementary CoQ10 reduced oxidative stress and beta-amyloid deposition while improving cognitive performance in transgenic mouse models of Alzheimer's disease [7][5].
Support for memory and cognitive function
Research shows CoQ10 improves learning and memory deficits induced by various pathological conditions [10]. CoQ10 therapy improved memory, retention, and learning in rat models of Alzheimer's disease, with substantial decreases in oxidative stress and increases in ATP levels within the cerebral cortex and hippocampus [1]. Treatment improved cognitive performance in Alzheimer's mice, as evidenced by improved learning compared to untreated controls [1].
Studies that scrutinised hippocampal synaptic plasticity in animals subjected to beta-amyloid injection found that oral CoQ10 at 50 mg/kg daily improved memory and neuroplasticity of neurons [5]. CoQ10 administration altered the expression of 12 proteins in the hippocampus and improved spatial memory in genetically modified mice with Alzheimer's pathology [1]. CoQ10 supplementation also improved short-term memory impairments in a rat model of Parkinson's disease [1].
Human evidence remains more limited. One-year ubiquinol supplementation improved cerebral vasoreactivity and reduced inflammation in males with mild cognitive impairment [1]. Patients with progressive supranuclear palsy showed improved cognitive tasks that involved the frontal lobe following CoQ10 administration [1]. Higher plasma CoQ10 levels relate to better cognitive and executive function in older adults, supporting the connection between mitochondrial health and brain performance [11].
Improved blood flow to the brain
Reduced cerebral blood flow contributes to impaired cognition in heart failure and ageing. CoQ10 positions itself as a potential therapeutic through cardiovascular improvements [1]. Higher CoQ10 bioavailability related to increased cerebral blood flow in patients with heart failure [1]. Cerebral blood flow relates positively to performance in different cognitive domains [1].
One trial assessed low-dose CoQ10 combined with mineral and multivitamin supplements in healthy females. Cerebral blood flow increased during cognitive tasks in the treatment group, though task performance showed no immediate changes [1]. This suggests CoQ10 influences brain perfusion even when cognitive benefits require longer treatment periods to show up.
What the Science Says: Evidence from Clinical Studies
Studies on CoQ10 and cognitive performance
Clinical trials analysed CoQ10 for brain health and produced inconsistent outcomes in a variety of populations. Out of eight human trials with healthy subjects and disease states, four showed beneficial effects on cognition. Two showed increased cerebral blood flow [12]. But many studies report no cognitive benefit whatsoever.
Research remains scarce in healthy populations. A trial with 106 females aged 25-49 years receiving 4.5 mg CoQ10 daily found cerebral blood flow increased substantially during cognitive tasks. Task performance remained unchanged [12]. Another study using 100 mg ubiquinol daily in 90 participants revealed borderline evidence of improved cognitive function [4]. Participants who were normal at baseline showed substantial memory improvements after 34 weeks. They also had better attention and processing speeds [12].
Disease populations present mixed results as well. CoQ10 at 1200 mg daily showed no detectable effects on cerebrospinal fluid biomarkers or cognition in Alzheimer's patients [12]. A trial with 69 mild cognitive impairment patients receiving 200 mg ubiquinol for 12 months improved cerebral vasoreactivity in males. It produced no cognitive changes that were statistically significant in either sex [4][12].
Parkinson's disease studies echo these disappointing outcomes. Early research suggested benefits at 1200 mg daily, but recent meta-analyses confirm CoQ10 provides no symptomatic benefit. It does not slow functional decline [2]. Patients with progressive supranuclear palsy showed improved frontal lobe task performance [4]. Chronic fatigue syndrome patients experienced improved working memory and arithmetic performance [4].
Research on age-related brain health
A study of 64 older adults aged 65-99 years identified a substantial association between plasma CoQ10 levels and cognitive functioning, especially when you have executive function. This held true after controlling for physical activity and nutritional status [13]. The findings suggest cognitive decline relates to reduced antioxidant defences. Low CoQ10 levels reflect this [13].
Animal research demonstrates more consistent benefits. Aged rats receiving 300 mg/kg daily for two weeks showed reversed memory impairment in recognition tests [14]. The supplementation reversed ageing-associated reductions in ATP production and mitophagy-related proteins. It also reversed oxidative stress markers in the hippocampus [14]. High-dose CoQ10 initiated at 17.5 months improved spatial learning efficiency in water maze tests after six weeks in mice [15].
Limitations of current research
The disparity between preclinical and clinical outcomes may reflect differing abilities. Knowing how to cross the blood-brain barrier differs in rodents versus humans [6]. Oral administration in rats at 200 mg/kg daily for one to two months increased cerebral cortex CoQ10 levels by 30-40% [6]. Mice receiving emulsified CoQ10 for seven days showed increased brain mitochondrial levels [6]. No clinical studies have demonstrated orally administered CoQ10 crossing the blood-brain barrier and accessing human brain tissue [6].
Additional limitations include differing testing procedures and inconsistent cognitive assessments. Different CoQ10 preparations have varying bioavailability [12]. Small sample sizes may produce insufficient statistical power rather than true absence of effect [16]. Future studies require longer treatment durations and wider cognitive assessment ranges. They should focus on populations where cognitive decline is greatest to evaluate CoQ10's therapeutic potential [17][18].
How to Use CoQ10 for Brain Health
Recommended dosages for adults over 55
Standard dosages range between 100-200 mg daily for adults over 55 [19][20]. Healthcare providers often suggest individuals above 50 take at least 100 mg daily, with an additional 100 mg for every decade thereafter [9]. This recommendation stems from research showing the body requires around 500 mg of CoQ10 daily from both endogenous production and dietary sources [21].
Studies have used doses ranging from 50 to 1,200 mg in adults [22]. Twice-daily supplementation with 100 mg raises plasma levels from 0.90 to 3.25 mcg/mL, the threshold that's therapeutically effective for cardiovascular disease [21]. Dosages up to 1,200 mg daily have been studied safely [23]. CoQ10 demonstrates excellent safety, even with chronic exposure to 900 mg daily [10].
Ubiquinol vs ubiquinone: which form is better?
Ubiquinone represents the oxidised form, whilst ubiquinol exists as the active, reduced form [24]. Research shows ubiquinol achieves higher plasma concentrations in older adults. A study of participants over 55 found ubiquinol increased plasma CoQ10 levels compared to ubiquinone [10]. Healthy adults over 60 experienced higher bioavailability with ubiquinol [21].
But CoQ10 appears in blood almost exclusively as ubiquinol, even when consumed as ubiquinone [10]. The body converts ubiquinone to ubiquinol, though this conversion becomes less efficient with age [24]. Ubiquinol offers advantages for maximum bioavailability after 40 [24].
Best time to take CoQ10
CoQ10 absorption peaks around 6 hours after ingestion [25][10]. You may maximise energy benefits and prevent sleep disruption by taking it in the morning [25]. Some individuals report sleep disturbance when taking CoQ10 late in the day [26].
Factors that affect CoQ10 absorption
CoQ10 is fat-soluble and requires dietary fat to absorb well [19][23]. Taking it with meals containing healthy fats enhances bioavailability [26]. Soft-gel capsules containing ubiquinone or ubiquinol show superior absorption compared to other formulations [27]. Individual physiological factors also influence how well CoQ10 reaches the bloodstream [27].
Combining CoQ10 with Other Brain-Supporting Habits
CoQ10 for brain health works best when you combine it with supportive lifestyle practises. Research confirms that multiple healthy behaviours together produce greater cognitive benefits than any single intervention [7].
Diet and nutrition for optimal brain health
The MIND diet shows promise for preserving cognitive function after 55. This eating pattern combines Mediterranean and DASH approaches, emphasising leafy greens, vegetables, berries, nuts, whole grains, and fish whilst limiting red meat, butter, and cheese [5][28]. Studies relate adherence to Mediterranean-style eating with lower dementia risk [5]. Nutrient-dense foods support brain cell energy production and reduce inflammation [29]. Choose foods high in vitamins and fibre, low in animal fats [5].
Exercise and mental activity
Physical activity maintains cognitive sharpness in older adults [5]. Federal guidelines recommend at least 150 minutes of moderate-intensity activity weekly [30][1]. Regular exercise improves memory and reduces cognitive decline risk. It may also lower Alzheimer's disease development [1]. Cognitive training and mentally demanding activities like learning new skills provide benefits beyond socialisation [5].
Quality sleep and stress management
Adults need 7-9 hours of sleep each night for optimal brain function and mental clarity [28]. Sleep supports memory consolidation, emotional regulation, and cognitive performance [8]. Sleep disorders relate to cognitive dysfunction [11]. Stress management through relaxation techniques supports both sleep quality and brain health [31].
Conclusion
CoQ10 supplementation offers genuine promise to maintain brain health after 55, especially as natural production declines. The evidence supports its role in cellular energy production, oxidative stress protection and mental stamina. While clinical trials show mixed results, the science remains compelling if you have cognitive fatigue or take statins.
Most adults over 55 benefit from 100-200 mg daily. Ubiquinol provides superior absorption. Note that CoQ10 works best with proper nutrition and regular exercise, quality sleep and mental stimulation. Call it one valuable component of a detailed approach to preserve cognitive function as you age rather than a standalone solution.
FAQs
Q1. What is the recommended CoQ10 dosage for adults over 55? For adults over 55, the recommended dosage is typically 100-200 mg daily. Healthcare providers often suggest starting with at least 100 mg per day, with some recommending an additional 100 mg for every decade beyond 50. Dosages up to 1,200 mg daily have been studied safely, though most people find 100-200 mg sufficient for supporting brain health and energy production.
Q2. Can CoQ10 supplementation help improve energy levels and reduce fatigue? Yes, CoQ10 supplementation has been shown to significantly reduce fatigue and enhance mental energy. Research involving over 1,000 participants found that CoQ10 produced statistically significant reductions in fatigue scores compared to placebo groups. The effect is particularly noticeable in older adults, as CoQ10 plays a crucial role in cellular energy production within the mitochondria.
Q3. Is CoQ10 beneficial for elderly individuals? CoQ10 offers several benefits for senior citizens, particularly those over 55. Accumulating evidence suggests that supplementation can help reduce oxidative stress, support cognitive function, and improve physical performance. As natural CoQ10 production declines with age—dropping to approximately half by age 65—supplementation becomes increasingly valuable for maintaining overall health and vitality in older adults.
Q4. Does CoQ10 support cognitive function and memory? CoQ10 has shown promise in supporting brain function and memory. Studies demonstrate that it can improve learning and memory deficits, reduce oxidative stress in brain tissue, and enhance cognitive performance. Research has found associations between higher plasma CoQ10 levels and better cognitive and executive function in older adults, though results vary across different populations and study designs.
Q5. Which form of CoQ10 is better absorbed—ubiquinol or ubiquinone? Ubiquinol, the reduced form of CoQ10, generally offers superior absorption in adults over 55. Research shows that ubiquinol achieves significantly higher plasma concentrations compared to ubiquinone, particularly in older individuals. This is because the body's ability to convert ubiquinone to the active ubiquinol form becomes less efficient with age, making direct ubiquinol supplementation more effective for maximum bioavailability.
References
[1] - https://www.cdc.gov/physical-activity/features/boost-brain-health.html
[2] - https://pmc.ncbi.nlm.nih.gov/articles/PMC9054193/
[3] - https://cymbiotika.com/blogs/health-hub/is-coq10-good-for-the-brain-exploring-the-neuroprotective-potential-of-coenzyme-q10?srsltid=AfmBOor-erPG_ljMUshKPOsT4kMKB45sQcrUERz5_Z1yu3VXowBsyaSq
[4] - https://www.mdpi.com/2072-6643/17/17/2896
[5] - https://www.nia.nih.gov/health/brain-health/cognitive-health-and-older-adults
[6] - https://pmc.ncbi.nlm.nih.gov/articles/PMC12027549/
[7] - https://news.med.miami.edu/lifelong-lifestyle-changes-brain-health/
[8] - https://www.openaccessjournals.com/articles/the-influence-of-sleep-on-cognitive-function-and-mental-health-17951.html
[9] - https://bostonheartdiagnostics.com/should-you-be-taking-coq10/
[10] - https://pmc.ncbi.nlm.nih.gov/articles/PMC7146408/
[11] - https://pmc.ncbi.nlm.nih.gov/articles/PMC11439658/
[12] - https://pmc.ncbi.nlm.nih.gov/articles/PMC12430131/
[13] - https://pubmed.ncbi.nlm.nih.gov/35908233/
[14] - https://www.sciencedirect.com/science/article/abs/pii/S0531556522002583
[15] - https://www.nutraingredients.com/Article/2013/09/30/CoQ10-may-reverse-effects-of-age-related-mental-decline-Mouse-data/
[16] - https://www.news-medical.net/news/20250909/Experts-review-the-evidence-on-coenzyme-Q10-and-cognitive-decline.aspx
[17] - https://pmc.ncbi.nlm.nih.gov/articles/PMC6549544/
[18] - https://www.frontiersin.org/journals/ageing-neuroscience/articles/10.3389/fnagi.2019.00103/full
[19] - https://www.healthline.com/nutrition/coq10-dosage
[20] - https://www.vinmec.com/eng/blog/coenzyme-q10-coq10-dosage-how-much-should-you-take-each-day-en
[21] - https://pmc.ncbi.nlm.nih.gov/articles/PMC7278738/
[22] - https://www.webmd.com/diet/supplement-guide-coenzymeq10-coq10
[23] - https://www.naturemade.com/blogs/health-articles/best-time-to-take-coq10-supplements?srsltid=AfmBOooQoOvSDPuW6Qb_oGVtHyTzmR5UYkGzaS0YwWQXlGIYOFoj-imK
[24] - https://www.livemomentous.com/blogs/all/ubiquinone-vs-ubiquinol?srsltid=AfmBOoqLXEWTzalw6lY4pSECLxB1M2d2kBUj8gC_l8ngd5vY4O-6aM5j
[25] - https://www.health.com/best-time-to-take-coq10-11844522
[26] - https://www.boltpharmacy.co.uk/guide/when-is-the-best-time-to-take-coq10
[27] - https://www.sciencedirect.com/science/article/abs/pii/S089990071830488X
[28] - https://www.mayoclinic.org/healthy-lifestyle/healthy-ageing/in-depth/brain-health-tips/art-20555198
[29] - http://www.ifm.org/articles/nutrition-cognitive-health
[30] - https://www.nia.nih.gov/news/lifelong-exercise-promotes-brain-health-older-adults
[31] - https://www.bannerhealth.com/healthcareblog/teach-me/how-sleep-can-affect-stress
