What is vitamin D3?

Vitamin D, also known as cholecalciferol, is a fat-soluble hormone that is part of one of the many nutrients that the body needs in order to stay healthy. The term "vitamin D" refers to several different forms, of which the two most active in the body are:

 Vitamin D2 (ergocalciferol) produced by plants.

 Vitamin D3 (cholecalciferol) which is synthesized by the skin under the action of the sun or provided by food [1].

How does vitamin D3 interact in the body ?

 Vitamin D3 plays an important and protective role in the regulation of the inflammatory response, in the development of cardiovascular disease related to atherosclerosis.

 It is a hormonal micronutrient essential for the proper functioning of the entire body, whose essential role is to regulate the amount of phosphate and calcium. Thus, it allows an optimal mineralization of certain tissues such as bones, cartilage or teeth, by supplying the body with optimal quantities nutrients.

 It also plays an important role in maintaining muscle function and strengthening the immune system.

What are the key benefits of intaking vitamin D3?

One of the best-known benefits of this vitamin D3 is its ability to improve the health of the musculoskeletal system. As with calcium and phosphorus, vitamin D helps to build bones and maintain a health bone by allowing them to be absorbed. Its mechanism also helps to block the release of parathyroid hormone, which is responsible for reabsorbing bone tissue, leading to thinning and weakening of bones with an increased risk of fractures. Vitamin D3 helps in the treatment [2] and prevention of osteomalacia, rickets, osteoporosis and other bone disorders. It is used to treat pseudohypoparathyroidism, hypoparathyroidism, familial hypophosphatemia [3]. Finally, vitamin D3 keeps the muscle system efficient and reduces muscle spasms. It acts as a macrophage in the bloodstream. These are large specialized cells that are part of the immune system and attack foreign pathogens.

What is the link between vitamin D3 and cancer?

Several scientific studies have shown a strong correlation between vitamin D3 and cancer. Vitamin D3 deficiency is often associated with an increased risk of various cancers such as breast, ovarian, prostate and colon cancer [4]. Improving the nutritional status of calcium and vitamin D3 significantly reduces the total cancer risk in postmenopausal women. [5]

Why combine vitamin D3, vitamin K2-MK7 and vitamin C?

Over the past decade, it has become clear that vitamin K has an important role to play in human health that goes beyond its well-established function in blood clotting [6]. Indeed, the combination of the two vitamins is beneficial and allows the activation and synthesis of osteocalcin in the presence of vitamin D3. Vitamin K2 is the substance that gives life to the vitamin D dependent protein. While vitamin D3 acts as a signal molecule, telling cells to make certain proteins, vitamin K2 activates these proteins by giving them the physical ability to bind themselves to the calcium. In some cases, these proteins directly coordinate the movement or the organisation of calcium itself; in other cases, calcium acts as a glue to hold the protein in a certain form. In all these cases, the proteins are functional only after they have been activated by vitamin K2 [7]. More interestingly, vitamin C has been shown to specifically influence the activity of 25 (OH) D3-1-hidroxylase ("non-active" vitamin D3), the enzyme responsible for the transformation of 25 (OH) D3 into 1,25 (OH) 2D3, the active form of vitamin D3. Its concentration is essential for optimal absorption of calcium from the gut and for bone mineralization. The activation of this hormone, vitamin D3, is essential to ensure optimal synergy and efficiency in the body.

What is the best form of vitamin D3 ?

Vitamin D extracted from lanolin is a form of hormone known as "bio-identity", i.e. biologically identical to that which humans produce naturally.

Benefits of the vitamin D3 complex under liposomal encapsulation:

The process of liposomal encapsulation allows the intact passage of the vitamin complex through the digestive system without being affected by the digestive juices and delivers the vitamins effectively directly into the cells of the body. Chemotacticism works in an obvious way and allows the liposomes to be attracted by the same human cells body by the fact that they are "bio-identical" and thus releases the active ingredients, here the vitamins, into the target organs. This process offers the highest level of bioavailability.

Reference:

[1]: Sezer Acar, Korcan Demir and Yufei Shi,Genetic Causes of Rickets, 10.4274 / jcrpe. 2017. S008

[2]: University of Texas Southeastern Medical Center, Dallas.Calcium, estrogen, and progestin in the treatment of osteoporosis.1994 Aug;20(3):691-716.

[3]: "Calcitriol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 9 April 2019; British national formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 1050–1051.

[4]: wbgrant@infi.net; An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation. Cancer 2002 Mar 15;94(6):1867-75.

[5]: Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. VITAMIN D and calcium supplementation reduces cancer risk: results of a randomized trial.2007 Jun;85(6):1586-91.

[6]: Vitamins and Fine Chemicals Division, Human Nutrition & Health, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland. Vitamin K and bone health. Nutrition. 2001 Oct;17(10):880-7

[7]: Margueritta S. El Asmar,1 Joseph J. Naoum,2 and Elias J. Arbid2; Vitamin K Dependent Proteins and the Role of Vitamin K2 in the Modulation of Vascular Calcification: A Review; Oman Med J. 2014 May; 29(3): 172–177.